Chronic Metabolic Acidosis in Chronic Kidney Disease

Consequences of Metabolic Acidosis in Chronic Kidney Disease Patients

Metabolic acidosis is an inevitable complication associated with progressive loss of kidney function. It appears when glomerular filtration rate (GFR) falls below 25 ml/min/ 1.73 m. Metabolic acidosis arises from the difference between the excretion of hydrogen and the synthesis of ammonia ions. Damaged renal tubules cannot contribute in maintaining the acid base balance by reabsorbing the dail...

Metabolic acidosis and the progression of chronic kidney disease

Metabolic acidosis is a common complication of chronic kidney disease. Accumulating evidence identifies acidosis not only as a consequence of, but as a contributor to, kidney disease progression. Several mechanistic pathways have been identified in this regard. The dietary acid load, even in the absence of overt acidosis, may have deleterious effects. Several small trials now suggest that the t...

Metabolic acidosis and progression of chronic kidney disease.

Effect of metabolic acidosis on progression of chronic kidney disease.

METABOLIC ACIDOSIS, TRADITIONALLY defined as a reduction in serum HCO3 concentration ([HCO3 ]) often associated with a detectable reduction in blood pH, is a common accompaniment of progressive chronic kidney disease (CKD) (7). The metabolic acidosis even when mild is not without consequences: increased degradation of muscle protein with muscle wasting (1), reduced albumin synthesis with result...

Vitamin deficiencies in chronic kidney disease